Alice, always portrayed by Milla Jovovich, is the protagonist of the Resident Evil film series. The plot of each film generally revolves around her struggle with the Umbrella Corporation. Alice also appears in the film's novelizations which go into greater detail of her backstory. In the first film, Resident Evil, Alice is depicted as suffering from amnesia, gradually realizing her abilities as a highly trained private security operative. In Apocalypse and Extinction her character is represented as "a supremely efficient killing machine" and bio-weapon. Alice is an "iconic figure and is closely associated with the series," becoming more skilled and rugged throughout the series. Alice's superhuman abilities, as well as the use of various styles of martial arts and gunplay make her something of a superhero character. For example, in Apocalypse, after her exposure to the T-virus, she displays psychic powers akin to those of Alexia Ashford. In Extinction, her powers are even more developed - she displays even greater control over her telekinesis (although she experiences blackouts and massive headaches if she pushes her powers too far). In Resident Evil: Afterlife, Alice's superhuman abilities have been taken away by Wesker, who injected her with a serum that disabled her T-virus cells. However, at the end of Resident Evil: Retribution, Wesker injects her with the T-Virus and restores her powers, saying that Alice and her powers are the last, best hope for humanity.
Alice is an original character created for the films, although writer Paul W. S. Anderson noted that Alice was based on the strong women in the Resident Evil games. Anderson initially toyed with the idea of the film being an allegory to Alice's Adventures in Wonderland, but the idea was not followed through completely. Despite this, the film contains various references to the work, which included Alice's name. Although the name Alice was given as the character's name prior to Resident Evil's release and is listed in the credits, her name is not actually spoken until the second film, Resident Evil: Apocalypse.